Fresh from his four-goal haul at Gloucester City a week earlier, Mooney notched another treble to sink Farsley Celtic at the Jakemans Community Stadium.
He turned away from Rudy Misambo to hand United a 30th minute lead, before heading home Martin Woods' free-kick six minutes after half-time and exchanging passes with Michael Gyasi six minutes from time to seal the matchball and United's latest home win.
Mooney's heroics meant United managed back-to-back hat-tricks for the first time since 1973 - and the player himself became the first to record successive trebles since Peter Thompson in 1966.
The Pilgrims had found Farsley well-organised and resolute in the opening stages - but were firmly building up a head of steam before their breakthrough arrived. Jai Rowe threaded MOONEY through and he powered away from Misambo to beat Zan-Luk Leban with a low drive that kissed the post on its way home.
United were indebted to Cameron Gregory on the stroke of half-time, with the Boston keeper standing tall to deny Darren Stephenson, who had found himself in acres of space in the penalty area.
The Pilgrims added their second goal when Woods delivered a pinpoint ball from a left-sided free-kick and MOONEY sent an unmarked header past Leban.
Leban flew across goal to keep out Dylan Hill's long-range drive before MOONEY set Gyasi away down the United right before arriving in the nick of time to tuck home a low drive from 18 yards to write himself further into United folklore.
Boston (3-4-1-2): Cameron Gregory; Jai Rowe, Michael Bostwick, Brad Nicholson; Sam Smart (Michael Gyasi 80), Dylan Hill, Martin Woods, Ethan Sephton (Lucien Mahovo 82); Keaton Ward (Deji Sotona 86); Kelsey Mooney, Jimmy Knowles. Subs (not used): Keziah Martin, Sam Essien.
Farsley (3-5-2): Zan-Luk Leban; Harry Sheridan, Rudy Misambo, Tom Allan; Sam Leverett (Ryan Watson 79), Ben Atkinson (Jordan Carroll 87), Conor Branson, Jack Evans, Lewis Turner; Michael Coulson, Darren Stephenson (Clayton Donaldson 74). Subs (not used): Chris Atkinson, Harry Allen (gk).
Referee: Tommy Breen.
Attendance: 1,522 (30 visitors).
PIC: Russell Dossett.