Following earlier home-and-away successes over Kettering Town, Bradford Park Avenue, Southport and Kidderminster Harriers, United will be now aiming for a fifth double following a 2-0 home win over Spartans in November.
Lee Clark's struggling side enjoyed a renaissance in the autumn but still find themselves in the bottom two and have lost to King's Lynn Town and AFC Telford United during the last seven days.
They have picked up three wins and three draws, alongside eight defeats, on home soil so far this season.
The Pilgrims are still likely to be without the services of injured midfielder Brad Abbott (ankle) but striker Jake Wright is back in contention following a shoulder injury.
Last season's corresponding fixture ended 3-0 in Spartans' favour.
Saturday's match referee is Adam Williamson, who last took charge of the Pilgrims in August at home to Guiseley.
POSTCODE FOR SAT NAV: NE24 3JE.
BUSA COACH DEPARTURE: 9.00am.
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