The ambitious United Counties League outfit provide the Pilgrims’ second opponents of pre-season at Sir Halley Stewart Field (kick-off 7.45pm).
Boston boss Dennis Greene will make a call on goalkeeper Ashley Timms’ fitness ahead of kick-off, while the match will come too soon for striker Marc Newsham, who is on his way home following the World University Games in Russia.
Midfielder Gary Mills could play a more prominent role after a second half substitute outing against Lincoln United on Tuesday.
Spalding have a number of former Boston players in their squad, including Nathan Stainfield, Lee Canoville, Danny Steadman, Chris Hall, Lee Beeson, Dan Cotton and Tony Battersby.
The Sir Halley Stewart Field postcode is PE11 1DA.
Team news and goal flashes will be available on Twitter via @bostonunited.