The Pilgrims' under-23s head to the Zeeco Stadium to face Southern League Premier Central promotion chasers Stamford AFC (kick-off 7.45pm).
Led by United's head of football development and U19s head coach Jamie Raynor, the Pilgrims will utilise an array of their young players in the south of the county.
Goalkeeper Jake Lovelace is expected to make his first competitive appearance of the season after recovering from injury.
Midfielder Jude Frostick will also feature, having been on the first team bench a number of times over recent weeks following his arrival from Fakenham Town.
Should the match end all-square after 90 minutes, penalties will be used to determine the winners.
LIVE COVERAGE
X updates will be available via @bostonunited throughout the evening.
TICKETS
Away supporters can pay by cash or card on the turnstiles.
KIT WATCH
United will be wearing their home kit of amber and black.
PIC: Chris Bray.