The Sandgrounders endured a seven-match winless streak at the start of the National League North campaign, but propelled themselves into a play-off position following an unbeaten 14-match run.
Over recent days, Southport have suffered back-to-back defeats at Kettering Town (2-1) and Chester FC (5-0) before bouncing back in style to win 3-0 at AFC Telford United on Tuesday evening.
United boss Paul Cox will check on the fitness of Jay Rollins, Jake Wright Jnr and James Hanson, who have all returned to training.
Jake Wright Snr, Paul Green, Andi Thanoj and Jordan Burrow remain sidelined.
Last season's corresponding fixture did not take place – with United winning the last Lincolnshire meeting between the sides in September 2019 (2-0).
LIVE COVERAGE
BBC Radio Lincolnshire online full-match commentary, courtesy of Dale Storey and Craig Singleton, is available (here).
TICKETS
The match is NOT all-ticket – but ticket purchases are recommended. Click here to buy a ticket.
TRANSPORT
Click here for a full guide on transport to and from the Jakemans Community Stadium - with car parking reserved exclusively for seasonal pass holders and club guests.
COVID GUIDANCE
Click here to read the club's updated guidance in relation to Covid-19.
ELLENDERS
Ellenders will be open from 11.00am.
HOSPITALITY
Doors for Club 85 and the executive boxes will open at 12.30pm.