The Pilgrims dropped into the bottom four courtesy of their 3-2 defeat at Kettering Town on Tuesday evening.
United boss Ian Culverhouse is poised to welcome attacker Billy Chadwick back into the squad, following the extension of his loan spell from Hull City.
Goalkeeper Cameron Gregory will complete his three-match suspension on Saturday.
Alfreton, who were beaten 1-0 at the Jakemans Community Stadium earlier in the season, are currently in 11th position with 38 points to their credit.
Last season's corresponding fixture ended 1-1, with Luke Shiels' goal cancelled out by Matt Rhead.
LIVE COVERAGE
BBC Radio Lincolnshire full-match commentary, courtesy of Rob Makepeace and Craig Singleton, is available.
Twitter updates will be available via @bostonunited throughout the afternoon.
TICKETS
Away supporters can purchase tickets here.
The match is segregated, with United allocated the Alma Street end.
KIT WATCH
United will be wearing their home kit of amber and black.
PIC: Nikolay Hristov.