The Pilgrims, fresh from Saturday's Emirates FA Cup heroics at Carshalton Athletic, begin a cycle of three league matches inside seven days ahead of two more cup away days at the end of the month.
The Spennymoor fixture was postponed on August 10 due to the Moors being advised against playing on their brand-new playing surface ahead of schedule.
United boss Craig Elliott will check on the bumps and bruises picked up in southwest London at the weekend, with centre-half Simon Ainge a particular doubt after limping off at half-time.
Jordan Thewlis will be aiming to resume where he left off in the Pilgrims' last league encounter where he netted a hat-trick at AFC Telford United.
Spennymoor have picked up considerably after a slow start to the season and moved into the play-off places for the first time at the weekend after a 1-0 win over Southport.
Last season's corresponding fixture ended 1-0 to the Moors.
Tuesday's match referee is Adam Herczeg, who presided over United's 2-0 win at Stockport County in September 2018.
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