The Pilgrims will entertain the under-21 sides of Leeds United, Sunderland, Newcastle United and Middlesbrough over the next four months.
All matches will take place at the Jakemans Community Stadium (kick-off 7.30pm):
Tuesday October 1 v Leeds United
Tuesday November 5 v Sunderland
Tuesday December 3 v Newcastle United
Tuesday January 21 v Middlesbrough
Admission details and prices will be published in the near future.