United make the journey to Croft Park looking to make it back-to-back wins following their 4-1 home victory over Curzon Ashton last weekend.
Middleton is back from his two-match ban while striker Gavin Allott could also return following a thigh injury sustained against Chorley on March 16.
Allott's probable return would compensate for the loss of fellow striker Jake Wright, who has returned to York City at the end of his loan spell with the Pilgrims.
Bradford City midfielder Cameron Hawkes, who joined the Pilgrims on loan on the eve of the Curzon fixture, could feature for the first time.
Spartans are one place and one point behind the Pilgrims, with one match in hand, ahead of Saturday's contest in the northeast.
United, who were 4-0 victors over Blyth earlier this season, were beaten 5-2 in last season's corresponding fixture.
Saturday's match referee is Sam Barrott, who has taken charge of United's home wins over Hereford FC and FC United of Manchester so far this season.
POSTCODE FOR SAT NAV: NE24 3JE.
BUSA COACH DEPARTURE: 9.30am.
UNITED COLOURS: Purple.
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